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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIK2
All Species:
17.88
Human Site:
S674
Identified Species:
35.76
UniProt:
Q9H0K1
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H0K1
NP_056006.1
926
103915
S674
P
Q
L
S
P
R
Q
S
L
E
T
Q
Y
L
Q
Chimpanzee
Pan troglodytes
XP_508750
883
99166
S631
P
Q
L
S
P
R
Q
S
L
E
T
Q
Y
L
Q
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_546528
993
110460
S748
P
Q
L
S
P
R
Q
S
L
E
A
Q
Y
L
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFH6
931
104180
S674
P
Q
L
S
P
Q
Q
S
L
E
T
Q
Y
L
Q
Rat
Rattus norvegicus
Q9R1U5
776
84890
A550
P
F
L
G
S
Q
S
A
T
P
V
L
Q
S
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511894
801
88312
Q576
A
L
L
P
I
S
F
Q
E
G
R
R
A
S
D
Chicken
Gallus gallus
Q9IA88
798
88848
R573
V
S
F
Q
E
G
R
R
A
S
D
T
S
L
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
V867
L
Q
G
A
S
L
K
V
P
G
L
E
G
Y
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_569972
1398
149888
T1128
G
K
H
H
P
L
L
T
L
P
H
H
H
A
H
Honey Bee
Apis mellifera
XP_397175
718
80391
P493
S
S
L
P
S
C
T
P
P
P
P
M
S
P
S
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
T909
L
S
G
A
P
S
S
T
G
A
S
S
Q
Q
Y
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
T287
L
A
V
S
P
P
D
T
V
E
Q
A
K
K
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.2
N.A.
84.7
N.A.
90.8
43.2
N.A.
45.2
45.4
N.A.
31.5
N.A.
29.6
37.4
23.8
N.A.
Protein Similarity:
100
95.3
N.A.
87.5
N.A.
94.4
56.7
N.A.
58.6
58.9
N.A.
45.2
N.A.
40
49.3
38.1
N.A.
P-Site Identity:
100
100
N.A.
93.3
N.A.
93.3
20
N.A.
6.6
6.6
N.A.
6.6
N.A.
13.3
6.6
6.6
N.A.
P-Site Similarity:
100
100
N.A.
93.3
N.A.
100
33.3
N.A.
13.3
13.3
N.A.
26.6
N.A.
33.3
6.6
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
17
0
0
0
9
9
9
9
9
9
9
0
% A
% Cys:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
9
0
0
0
9
0
0
0
9
% D
% Glu:
0
0
0
0
9
0
0
0
9
42
0
9
0
0
0
% E
% Phe:
0
9
9
0
0
0
9
0
0
0
0
0
0
0
0
% F
% Gly:
9
0
17
9
0
9
0
0
9
17
0
0
9
0
9
% G
% His:
0
0
9
9
0
0
0
0
0
0
9
9
9
0
9
% H
% Ile:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
9
% I
% Lys:
0
9
0
0
0
0
9
0
0
0
0
0
9
9
0
% K
% Leu:
25
9
59
0
0
17
9
0
42
0
9
9
0
42
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
42
0
0
17
59
9
0
9
17
25
9
0
0
9
0
% P
% Gln:
0
42
0
9
0
17
34
9
0
0
9
34
17
9
42
% Q
% Arg:
0
0
0
0
0
25
9
9
0
0
9
9
0
0
0
% R
% Ser:
9
25
0
42
25
17
17
34
0
9
9
9
17
17
9
% S
% Thr:
0
0
0
0
0
0
9
25
9
0
25
9
0
0
9
% T
% Val:
9
0
9
0
0
0
0
9
9
0
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
34
9
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _